Agenda

Thursday, March 2, 2000
6 p.m.	Registration - Pick up badges and programs - Versailles IV Opening Reception and Poster Session - Versailles IV Co-Chairs: Paul A. Watkins and Robert Katz
7:00-7:30 p.m.	Reception
7:30-8:30 p.m.	Viewing of posters
8:30-9:30 p.m.	Viewing with authors by odd-numbered posters
9:30-10:30 p.m.	Viewing with authors by even-numbered posters. (Posters will remain displayed through 10:00 p.m. on March 3.)

Friday, March 3, 2000
7:30 a.m.	Continental Breakfast - Versailles IV
7:55 a.m.	Oral presentations - Versailles III

Morning Session :	Fatty acid uptake by and transport in the brain. Co-Chairs: Jacques H. Veerkamp and James A. Hamilton
7:55 a.m.	Welcome. Paul A. Watkins (All presentations are 20 minutes long and are followed by a 5 minute Q & A session directly relevant to the presentation)
8:00-8:25 a.m.	Structure of the microvascular endothelium. Lester R. Drewes
8:25-8:50 a.m.	The diffusion mechanism in model and biological membranes. James A. Hamilton
8:50-9:15 a.m.	Molecular barriers to lipid transport. Henry J. Pownall
9:15-9:40 a.m.	A model of coupled fatty acid transport and metabolism. Jean A. Schaffer
9:40-10:05 a.m.	The role of CD36 in fatty acid transport by various tissues. Nada Abumrad
10:05-10:30 a.m.	Coffee break - Versailles IV
10:30-10:55 a.m.	The role of membrane-associated proteins in cellular fatty acid uptake. Jan F. Glatz
10:55-11:20 a.m.	Structural and functional properties of eight FABP types. Jacques H.Veerkamp
11:20-11:45 a.m.	Mechanisms of fatty acid transport and targeting. Judith Storch
11:45 a.m.-12:30 p.m.	Round table discussion and recommendations. Discussant: Alexander Leaf
12:30-1:30 p.m.	Lunch - on your own

Afternoon Session :	Brain uptake, transport and metabolism of PUFA: In vivo and in vitro studies. Co-chairs: Arthur A. Spector and Steven A. Moore
1:30-1:55 p.m.	Sources of PUFA in the plasma. Arthur A. Spector
1:55-2:20 p.m.	Measurement of brain PUFA uptake by perfusion techniques. Quentin R. Smith
2:20-2:45 p.m.	NMR and isotope ratio MS studies of in vivo uptake and metabolism of PUFA by the rodent brain. Stephen C. Cunnane
2:45-3:10 p.m.	PUFA transport and utilization in the developing brain. John Edmond
3:10-3:40 p.m.	Coffee break - Versailles IV
3:40-4:05 p.m.	PUFA synthesis, transfer and metabolism by brain-derived cells in vitro. Steven A. Moore
4:05-4:30 p.m.	Lysophosphatidylcholine as a DHA carrier to the brain. Michel Lagarde
4:30-4:55 p.m.	Uptake, synthesis and metabolism of PUFA by the retina and retina-derived cells in vitro. Robert E. Anderson
5:00-5:45 p.m.	Round table discussion and recommendations.
	Discussant: Howard Sprecher

Evening Session :	Workshop Dinner and Dinner Lecture - Washington Room Hosts: Paul A. Watkins and Robert Katz
7:00-7:30 p.m.	Reception and cash bar
7:30-9:30 p.m.	Dinner Dinner Speaker: Alexander Leaf �Reflections on the effects of polyunsaturated fatty acids on brain, heart and coronary heart disease�


Saturday: March 4, 2000
7:30 a.m.	Continental Breakfast - Versailles IV
8:00 a.m.	Oral presentations - Versailles III

Morning Session :	The regulation and functions of DHA in neurons and neuronal membranes. Co-Chairs: Stanley I. Rapoport and Norman Salem, Jr.
8:00-8:25 a.m.	The protective effect of DHA in neuronal apoptosis. Hee-Yong Kim
8:25-8:50 a.m.	DHA accumulation and overaccumulation before birth. Impact on oxidative stress. Ephraim Yavin
8:50-9:15 a.m.	The role of DHA-containing phospholipids in modulating G-protein-coupled signaling pathways: The visual transduction pathway. Burton J. Litman
9:15-9:40 a.m	Quantifying in vivo fatty acid signaling and turnover in the central nervous system. Stanley I. Rapoport
9.40-10:10 a.m.	Coffee break - Versailles IV
10:10-10:35 a.m.	Plasmalogens, phospholipases and DHA turnover. Lloyd A. Horrocks
10:35-11:00 a.m.	Do DHA or other long‑chain PUFA have gene regulatory roles? James M. Ntambi
11:00-11:45 a.m.	Round table discussions and recommendations. Discussant: Robert E. Anderson
11:45 a.m.-12:45 p.m.	Lunch - on your own

A fternoon Session :	The roles of DHA in Zellweger syndrome, a representative peroxisomal biogenesis disorder. Co-chairs: Hugo W. Moser and Manuella Martinez
12:45-1:10 p.m.	Normal and defective neuronal membranes: Structure and function. James M. Powers
1:10-1:35 p.m.	The Zellweger syndrome animal model. Phillis L. Faust
1:35-2:00 p.m.	The DHA deficiency animal model. Norman Salem, Jr.
2:00-2:25 p.m.	Restoring DHA levels in the brains of Zellweger patients. Manuela Martinez
2:25-2:45 p.m.	Coffee break - Versailles IV
2:45-3:10 p.m.	DHA in other peroxisomal deficiency disorders. Hugo W. Moser
3:10-3:55 p.m.	Round table discussions and recommendations. Discussant: Michael J. Noetzel
4:00 p.m.	Adjournment

Organizing Committee: Paul A. Watkins, Kennedy Krieger Institute, Baltimore, Maryland James A. Hamilton, Boston University, Boston, Massachusetts Robert Katz, Omega-3 Research Institute, Inc., Bethesda, Maryland Arthur A. Spector, University of Iowa, Ames, Iowa Sponsors: Kennedy Krieger Institute Omega-3 Research Institute, Inc. Department of Neurology, Johns Hopkins University School of Medicine Financial Support for this Workshop was provided by an NIH Grant from: National Institute of Neurological Diseases and Stroke Office of Rare Diseases National Institute of Diabetes, and Digestive and Kidney Diseases The Organizers Gratefully Acknowledge Additional Financial Support from: BASF Corporation Body Bio Corporation Laxdale, Ltd. Martek Biosciences, Inc. Mead Johnson Nutritionals Nordic Naturals Ocean Nutrition Canada, Ltd. OmegaTech, Inc. Roche Vitamins, Inc. Ross Products Div., Abbott Laboratories Scientific Hospital Supplies United Leukodystrophies Foundation Planned publication of Proceedings Individual presentations, round table discussions and abstracts of posters are planned to be published in a single issue of the Journal of Molecular and Cellular Neuroscience.
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